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Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns

In a longitudinal cohort human study on 719 patients taking long-term warfarin, high homocysteine levels (17.2 mol/L) and serum folate (11.9 nmol/L) were not associated with bleeding events, but both were associated with cardiovascular events (myocardial infarction, ischemic stroke, peripheral arterial emboli) [288] (Table 2)

Flavonoids promote vasodilation in the afferent arterioles of the renal vasculature, which increases the glomerular filtration rate (GFR), leading to greater water excretion and lower BP (46)

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Clinical Trials Multiple clinical trials have investigated potential immunotherapy treatments for shellfish allergies, as summarized in Table 2